Answered by Jacob Laukaitis, marketer
The most tiring part of the nomad lifestyle is the fact that you cannot maintain close relationships to people in your life.
You see, when you travel alone, you are never in your comfort zone and thus you meet tons of wonderful people wherever you go. Sometimes you'll make really good friends with someone and spend the next few days or even weeks traveling together.
However, at some point you'll have to split and it might be the last time you'll ever see each other as both of you will be doing your own thing.
At the same time, you grow apart with your friends back home as you rarely meet each other and thus you're not such a big part of their lives anymore.
So if you live this kind of lifestyle for a very long time (say 10 years or more), you might lose all of your really close friends back home as they've built their lives without you and not have made any true friends while traveling as you haven't spent enough time together to form a deep connection...
I know it sounds a bit depressing, but there are solutions to this problem:
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